You want the database connection will be keep on connect to MySQL/MariaDB, just use pool_recycle parameter in method create_engine().
this setting causes the pool to recycle connections after the given number of seconds has passed. It defaults to -1, or no timeout. For example, setting to 3600 means connections will be recycled after one hour. Note that MySQL in particular will disconnect automatically if no activity is detected on a connection for eight hours (although this is configurable with the MySQLDB connection itself and the server configuration as well).